These are the Top 10 defeats of villains from indie games. First I want to say that I know Minecraft isn’t considered an indie game anymore, but I put in the list because it began as indie.
Plus any of these gameplay are mine. These are videos found on Youtube.
Timestamps to skip spoilers (or to go to the part you’re interested in):
(0:20) Flowey/Asriel Dreemur (Undertale)
(3:58) Dr. Fetus (Super Meat Boy)
(5:21) Purple Guy (FNaF)
(5:58) The Devil (Cuphead)
(7:05) Enderdragon (Minecraft)
(7:51) Spooky (Spooky’s house of Jumpscares)
(8:35) Hatty Hattington (BattleBlock Theater)
(9:49) The Principal (Kindergarten)
(11:45) Monika (DDLC)
(13:14) Mom (The Binding of Isaac)